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Bioaccumulation in Fish OECD 305

10th March 2020

At ibacon the bioaccumulation in fish according to OECD 305 is a routine study. It measures the residues of a test substance in fish after exposure to the test substance and subsequent depuration in test substance free media. The uptake of the test substance occurs either via direct accumulation of test substance from the aqueous environment (bioconcentration) or via food (biomagnification).
When technically feasible aqueous exposure designs are preferred. We are experienced in performing bioaccumulation studies with different fish species and varying substance properties. The studies are regularly designed as flow through studies and are carried out with juvenile fish. A control group and one or two test substance groups are assessed by collecting fish at each sampling point. The duration of the study depends on uptake and depuration kinetics.
Radiolabelled test substances can facilitate the analysis of water, food and fish samples, but also non-labelled substances can be assessed.
As a result the bioconcentration factor/biomagnification is calculated and growth and lipid corrected.
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